Much research has been conducted on what children need to grow up healthy, ready to learn, and to succeed in school. Many aspects of a child’s growth and development, family circumstance, and school success have been studied, analyzed, and reported on in an effort to help parents, educators, health care professionals, and policymakers better understand what they can do to assure a child’s success. A review of this research reveals two significant circumstances that seem to have the most impact on a child’s growth, development, and ultimate educational success: poverty and family interactions. Barring significant birth defects or injury, these two circumstances hold the key to virtually every aspect of a child’s life that affects his or her ability to grow up healthy and to learn. However, it must be noted that these two factors overlap in many respects and cannot be viewed in isolation. In addition, while it is recognized that a child’s behavior is what is sometimes most disruptive to the family, due to the child’s drug abuse, mental illness, disability, or other factors, the focus here is on the effects of outside factors on the growth and development of the otherwise normal, healthy child.